Fluctuations in Intraocular Pressure Increase the Trabecular Meshwork Extracellular Matrix
نویسندگان
چکیده
منابع مشابه
Fluctuations in intraocular pressure increase the trabecular meshwork extracellular matrix.
BACKGROUND/AIMS The trabecular meshwork (TM) tissue is constantly exposed to dynamic stress caused by intraocular pressure (IOP). The effects of such biomechanical stress on the TM have not been analyzed. This study developed an animal model of fluctuating IOP and evaluated the effects of these fluctuations on TM tissue. METHODS To create fluctuation in the IOP, one eye of adult SD rats was e...
متن کاملGenes upregulated in the human trabecular meshwork in response to elevated intraocular pressure.
PURPOSE To identify genes upregulated in perfused, intact human trabecular meshwork (TM) in response to elevated intraocular pressure (IOP). METHOD Two pairs of anterior segments of normal human eyes from postmortem donors were placed in culture and perfused 24 hours at constant flow (3 microl/min). After reaching baseline, the flow of one eye from each pair was raised to obtain an incrementa...
متن کاملCoordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork.
PURPOSE The microRNA-29 (miR-29) family has emerged, in various tissues, as a key modulator of extracellular matrix (ECM) homeostasis. In this study, the authors investigate the role of the miR-29 family in the regulation of ECM synthesis in the trabecular meshwork (TM) under basal and TGF-β2 stimulatory conditions. METHODS Human TM cells were incubated with 2.5 ng/mL activated, recombinant h...
متن کاملUnderstanding trabecular meshwork physiology: a key to the control of intraocular pressure?
he anterior and posterior chambers of the eye are filled with aqueous humor, a fluid with an ionic composition very similar to the blood plasma and with two main functions: to supply nutrients to the avascular structures of the eye, cornea, and lens and to maintain intraocular pressure (IOP) within its physiological range, because it is the volume of aqueous humor in the eye chambers that deter...
متن کاملTGF 2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
PURPOSE. Transforming growth factor (TGF)2 levels are elevated in glaucomatous human aqueous humor. TGF is a cytokine that alters extracellular matrix (ECM) metabolism, and excess ECM has been proposed to increase aqueous outflow resistance in the trabecular meshwork (TM) of glaucomatous eyes. This study was undertaken to investigate effects of TGF 2 on secretion of fibronectin and the protease...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2014
ISSN: 1421-9778,1015-8987
DOI: 10.1159/000358691